COX16

Across TCGA patient cohorts, COX16 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX16-associated genes across cancer lineages are RARRES2P7, CYP4F36P, and MIR4306. Each is linked with COX16 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX16-to-partner and partner-to-COX16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RARRES2P7 grouped by COX16-low versus COX16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX16→partner) and Y-score (partner→COX16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RARRES2P7 →	+0.113	+3.827	<.001	.003	3	2
UCEC	CYP4F36P →	+0.368	+3.520	.007	.002	3	1
UCEC	MIR4306 →	+0.401	+3.666	.002	.004	3	1
UCEC	RN7SL470P →	+0.366	+4.016	<.001	<.001	3	1
UCEC	MIR4662B →	+0.356	+4.555	<.001	.005	3	1
UCEC	RN7SL275P →	+0.161	+3.666	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

RARRES2P7 by COX16 expression — UCEC

Explore this box plot interactively →