COX16

Across TCGA cell cohorts, COX16 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,281 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible COX16-associated GO terms across cancer lineages are Mitochondrial tRNA methylation, tRNA 5'-leader removal, and Mitochondrial tRNA 5'-end processing. Each is linked with COX16 in more than 11 cancer types. Because this analysis shows association rather than direction, both COX16-to-partner and partner-to-COX16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial tRNA methylation grouped by COX16-low versus COX16-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COX16→partner) and Y-score (partner→COX16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Mitochondrial tRNA methylation →	+0.126	+1.126	<.001	.006	3	12
UPPER_AERODIGESTIVE_TRACT	tRNA 5'-leader removal →	+0.100	+0.635	.005	.005	3	11
BONE	Mitochondrial tRNA 5'-end processing →	+0.168	+0.874	<.001	<.001	3	11
OESOPHAGUS	Immunoglobulin heavy chain V-D-J recombination →	+0.192	+0.649	<.001	.002	3	11
OESOPHAGUS	Protein localization to condensed chromosome →	+0.189	+0.919	<.001	<.001	3	10
OVARY	Regulation of mitochondrial gene expression →	+0.067	+0.465	.004	.004	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,281 associations by consensus.

Mitochondrial tRNA methylation by COX16 expression — BLOOD_Myeloma

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