COX15

Across TCGA pan-cancer cohorts, COX15 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COX15 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COX15 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COX15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where COX15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.285	0.592	.003	12	view →
HNSC	OS	Median	II,III,IV	0.934	0.727	.025	10	view →
LUAD	OS	Quartile	All	1.000	0.628	.014	8	view →
COAD	DFS	Median	IV	0.432	0.944	.038	6	view →
LSCC	DFS	Quartile	All	0.852	0.492	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COX15–PDAC (DFS)

Open the PDAC breakdown →