COX15

Across TCGA cell cohorts, COX15 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COX15-associated genes across cancer lineages are FTHL17, OR10AG1, and SPHKAP. Each is linked with COX15 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX15-to-partner and partner-to-COX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTHL17 grouped by COX15-low versus COX15-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX15→partner) and Y-score (partner→COX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FTHL17 →	+2.737	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.032	+4.662	<.001	.005	3	1
LARGE_INTESTINE	SPHKAP →	+0.006	+5.415	.007	.004	3	1
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	BTNL2 →	+0.109	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FTHL17 by COX15 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →