COTL1P2

Across TCGA pan-cancer cohorts, COTL1P2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of COTL1P2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COTL1P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COTL1P2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where COTL1P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COTL1P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.169	.004	5	view →
KIRC	All	III,IV	+0.063	.035	1	view →
HNSC	All	III,IV	+0.060	.046	1	view →
THCA	All	II,III,IV	−0.036	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

COTL1P2–COAD

Open the COAD breakdown →