COTL1P1

Across TCGA pan-cancer cohorts, COTL1P1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of COTL1P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where COTL1P1 RNA is repressed in tumor relative to normal tissue. In most cancer types COTL1P1 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and THCA are the cancer types where COTL1P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COTL1P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−0.045	.005	6	view →
KICH	Male	All	−0.072	.036	1	view →
THCA	All	All	+0.017	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

COTL1P1–KIRP

Open the KIRP breakdown →