COTL1

Across TCGA pan-cancer cohorts, COTL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COTL1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COTL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated COTL1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, COAD, and HNSC are the cancer types where COTL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.685	0.418	<.001	59	view →
COAD	DFS	Median	II,III,IV	0.873	1.000	.013	48	view →
HNSC	OS	Tertile	III,IV	0.534	0.872	.003	48	view →
LUAD	DFS	Quartile	II,III,IV	0.822	0.228	.018	7	view →
CCRCC	OS	Median	III,IV	0.831	1.000	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COTL1–PDAC (OS)

Open the PDAC breakdown →