COTL1

Across TCGA patient cohorts, COTL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,897 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COTL1-associated proteins across cancer lineages are ARHGAP25, WAS, and CORO1A. Each is linked with COTL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both COTL1-to-partner and partner-to-COTL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COTL1 versus ARHGAP25 in OV, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COTL1→partner) and Y-score (partner→COTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGAP25 →	+0.811	+0.881	.007	.007	3	10
UCEC	WAS →	+0.481	+0.560	.002	.005	3	9
OV	CORO1A →	+0.580	+0.650	<.001	<.001	3	9
GBM	HCLS1 →	+0.528	+0.493	<.001	<.001	3	9
GBM	DEF6 →	+0.541	+0.777	<.001	<.001	3	9
GBM	RCSD1 →	+0.560	+0.755	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,897 associations by consensus.

COTL1 vs ARHGAP25 — OV

Explore this scatter interactively →