COTL1

Across TCGA patient cohorts, COTL1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,647 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COTL1-associated genes across cancer lineages are GRAP2, IL2RB, and CORO1A. Each is linked with COTL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both COTL1-to-partner and partner-to-COTL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COTL1 versus GRAP2 in HNSC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COTL1→partner) and Y-score (partner→COTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GRAP2 →	+0.810	+0.442	<.001	<.001	3	10
COAD	IL2RB →	+1.132	+0.425	<.001	<.001	3	10
BRCA	CORO1A →	+1.444	+0.781	<.001	<.001	3	10
GBM	IL21R →	+0.968	+0.354	<.001	<.001	3	10
HNSC	MAP4K1 →	+0.949	+0.573	<.001	<.001	3	10
LSCC	RASAL3 →	+1.003	+0.589	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,647 associations by consensus.

COTL1 vs GRAP2 — HNSC

Explore this scatter interactively →