COTL1

Across TCGA patient cohorts, COTL1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COTL1-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and ERK2. Each is linked with COTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COTL1-to-partner and partner-to-COTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COTL1-low versus COTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COTL1→partner) and Y-score (partner→COTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.067	+2.479	<.001	.010	3	2
UCEC	A-Raf_pS299 →	-0.122	-3.000	.023	.036	3	1
UCEC	ERK2 →	+0.268	+3.321	.002	.009	3	1
UCEC	INPP4B →	-0.367	-1.986	.011	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.247	-3.459	.001	.005	3	1
UCEC	Ku80 →	+0.219	+2.713	.039	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Caspase-7-cleavedD198 by COTL1 expression — UCEC

Explore this box plot interactively →