COTL1

Across TCGA cell cohorts, COTL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,361 significant associations in total. BONE shows the largest number of these associations.

The most reproducible COTL1-associated GO terms across cancer lineages are Protein depolymerization, Integrin-mediated signaling pathway, and Regulation of fibrinolysis. Each is linked with COTL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both COTL1-to-partner and partner-to-COTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein depolymerization grouped by COTL1-low versus COTL1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COTL1→partner) and Y-score (partner→COTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Protein depolymerization →	+0.123	+1.274	.007	.004	3	12
BONE	Integrin-mediated signaling pathway →	+0.237	+2.554	<.001	<.001	3	12
BONE	Regulation of fibrinolysis →	+0.418	+2.260	<.001	<.001	3	12
OESOPHAGUS	Ventricular cardiac muscle cell differentiation →	+0.289	+1.560	<.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Cellular response to nitric oxide →	+0.145	+1.615	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cellular response to reactive nitrogen species →	+0.145	+1.615	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,361 associations by consensus.

Protein depolymerization by COTL1 expression — URINARY_TRACT

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