CORO7

Across TCGA patient cohorts, CORO7 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORO7-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with CORO7 in more than 2 cancer types. Because this analysis shows association rather than direction, both CORO7-to-partner and partner-to-CORO7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CORO7-low versus CORO7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORO7→partner) and Y-score (partner→CORO7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.584	+1.938	.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.073	+3.169	.003	.018	3	2
UCEC	EGFR_pY1068 →	-0.195	-1.415	.018	.043	3	2
UCEC	Notch1 →	+0.106	+1.820	.021	.014	3	2
UCEC	TFRC →	+0.399	+2.584	.022	.010	3	2
UCEC	ATM →	-0.344	-2.446	.021	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Cyclin-B1 by CORO7 expression — UCEC

Explore this box plot interactively →