CORO6

Across TCGA pan-cancer cohorts, CORO6 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CORO6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CORO6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CORO6 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and PDAC are the cancer types where CORO6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CORO6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	−1.041	<.001	7	view →
HNSC	All	II,III,IV	−0.725	.006	6	view →
PDAC	All	All	−1.480	.005	4	view →
LSCC	All	All	−0.359	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CORO6–LUAD

Open the LUAD breakdown →