CORO6

Across TCGA patient cohorts, CORO6 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORO6-associated genes across cancer lineages are PDCD4, ATM, and Caspase-7-cleavedD198. Each is linked with CORO6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CORO6-to-partner and partner-to-CORO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CORO6-low versus CORO6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORO6→partner) and Y-score (partner→CORO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.523	-3.160	.010	.019	3	2
UCEC	ATM →	-0.507	-3.156	.010	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.881	+2.115	<.001	.019	3	2
UCEC	4E-BP1 →	+0.384	+2.199	.001	.033	3	2
UCEC	HER3 →	+0.352	+3.013	.003	.018	3	1
UCEC	MEK1 →	+0.412	+2.115	.009	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PDCD4 by CORO6 expression — UCEC

Explore this box plot interactively →