CORO1C

Across TCGA patient cohorts, CORO1C mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORO1C-associated genes across cancer lineages are STAT3_pY705, Bax, and 4E-BP1. Each is linked with CORO1C in more than 1 cancer types. Because this analysis shows association rather than direction, both CORO1C-to-partner and partner-to-CORO1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CORO1C-low versus CORO1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORO1C→partner) and Y-score (partner→CORO1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.399	-1.990	<.001	.002	3	2
UCEC	Bax →	+0.181	+1.372	.022	.022	3	2
UCEC	4E-BP1 →	+0.361	+2.700	<.001	.005	3	2
UCEC	eIF4E →	+0.147	+2.713	.034	.003	3	1
UCEC	eIF4G →	+0.259	+1.700	.011	.042	3	1
UCEC	A-Raf_pS299 →	-0.156	-2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

STAT3_pY705 by CORO1C expression — UCEC

Explore this box plot interactively →