COQ9

Across TCGA pan-cancer cohorts, COQ9 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of COQ9’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where COQ9 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types COQ9 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where COQ9 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COQ9 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−1.027	<.001	12	view →
COAD	Female	IV	−0.747	<.001	12	view →
HNSC	All	II,III,IV	−1.192	<.001	11	view →
PDAC	Male	All	−0.811	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

COQ9–CCRCC

Open the CCRCC breakdown →