COQ8B

Across TCGA pan-cancer cohorts, COQ8B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COQ8B data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COQ8B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COQ8B expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

UCEC, COAD, and PDAC are the cancer types where COQ8B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.384	0.850	.013	16	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
PDAC	OS	Median	All	0.901	0.748	.008	6	view →
LUAD	DFS	Quartile	II,III,IV	0.313	0.761	.014	4	view →
CCRCC	DFS	Median	IV	0.382	0.932	.031	4	view →
LSCC	DFS	Median	All	0.892	1.000	.024	2	view →
HNSC	DFS	Quartile	IV	0.899	0.659	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COQ8B–UCEC (DFS)

Open the UCEC breakdown →