COQ8B

Across TCGA pan-cancer cohorts, COQ8B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of COQ8B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COQ8B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types COQ8B is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

COAD, LSCC, and PDAC are the cancer types where COQ8B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COQ8B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.139	<.001	7	view →
LSCC	Female	All	+0.398	<.001	6	view →
PDAC	Female	All	+0.372	.002	4	view →
HNSC	All	II,III,IV	−0.123	.022	3	view →
CCRCC	All	All	−0.086	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

COQ8B–COAD

Open the COAD breakdown →