COQ8B

Across TCGA patient cohorts, COQ8B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ8B-associated genes across cancer lineages are Fibronectin, G6PD, and MEK1. Each is linked with COQ8B in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ8B-to-partner and partner-to-COQ8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by COQ8B-low versus COQ8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ8B→partner) and Y-score (partner→COQ8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.297	-3.312	.039	.010	3	1
UCEC	G6PD →	-0.298	-2.115	.035	.019	3	1
UCEC	MEK1 →	+0.368	+3.321	.021	.010	3	1
UCEC	Notch1 →	+0.150	+2.331	.015	.019	3	1
UCEC	p27_pT198 →	+0.103	+2.999	.027	.035	3	1
UCEC	PRAS40_pT246 →	+0.164	+2.128	.029	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Fibronectin by COQ8B expression — UCEC

Explore this box plot interactively →