COQ8B

Across TCGA cell cohorts, COQ8B mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COQ8B-associated genes across cancer lineages are ADRA1A, PRND, and FAM9A. Each is linked with COQ8B in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ8B-to-partner and partner-to-COQ8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by COQ8B-low versus COQ8B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ8B→partner) and Y-score (partner→COQ8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADRA1A →	+0.232	+4.705	<.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	FAM9A →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	1
BLOOD_Leukemia	FAM24A →	+0.061	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IZUMO3 →	+0.054	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ADRA1A by COQ8B expression — BLOOD_Leukemia

Explore this box plot interactively →