COQ8A

Across TCGA pan-cancer cohorts, COQ8A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COQ8A data layer compared with 19 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COQ8A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated COQ8A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, SKCM, and COAD are the cancer types where COQ8A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.828	.010	24	view →
SKCM	OS	Median	II,III,IV	0.352	0.738	.013	15	view →
COAD	OS	Median	All	0.464	0.873	.003	9	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LUAD	DFS	Median	All	0.213	0.676	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COQ8A–UCEC (DFS)

Open the UCEC breakdown →