COQ8A

Across TCGA pan-cancer cohorts, COQ8A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COQ8A data layer compared with 19 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COQ8A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COQ8A expression acts as an unfavorable survival marker, although some lineages such as PDAC and OV show a favorable association.

PDAC, UCEC, and OV are the cancer types where COQ8A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.849	0.677	.001	48	view →
UCEC	DFS	Quartile	II,III,IV	0.433	1.000	.018	12	view →
OV	DFS	Median	All	0.890	0.607	.040	4	view →
LUAD	OS	Tertile	All	1.000	0.775	.020	3	view →
GBM	OS	Median	All	0.462	0.606	.049	1	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COQ8A–PDAC (DFS)

Open the PDAC breakdown →