COQ8A

Across TCGA patient cohorts, COQ8A mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ8A-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and Notch1. Each is linked with COQ8A in more than 2 cancer types. Because this analysis shows association rather than direction, both COQ8A-to-partner and partner-to-COQ8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COQ8A-low versus COQ8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ8A→partner) and Y-score (partner→COQ8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.608	+1.434	.003	.027	3	3
UCEC	MEK1 →	+0.429	+2.807	<.001	.002	3	2
UCEC	Notch1 →	+0.194	+2.920	<.001	<.001	3	2
UCEC	PDCD4 →	-0.396	-1.736	.015	.007	3	2
UCEC	Rad50 →	-0.176	-1.440	.036	.024	3	2
UCEC	ATM →	-0.369	-2.102	.018	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by COQ8A expression — UCEC

Explore this box plot interactively →