COQ8A

Across TCGA cell cohorts, COQ8A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,246 significant associations in total. BONE shows the largest number of these associations.

The most reproducible COQ8A-associated GO terms across cancer lineages are Tetrapyrrole biosynthetic process, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, and Porphyrin-containing compound biosynthetic process. Each is linked with COQ8A in more than 12 cancer types. Because this analysis shows association rather than direction, both COQ8A-to-partner and partner-to-COQ8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tetrapyrrole biosynthetic process grouped by COQ8A-low versus COQ8A-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ8A→partner) and Y-score (partner→COQ8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Tetrapyrrole biosynthetic process →	+0.087	+1.002	<.001	<.001	3	13
OESOPHAGUS	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.081	+0.874	.003	.004	3	13
PANCREAS	Porphyrin-containing compound biosynthetic process →	+0.087	+1.002	<.001	<.001	3	13
CNS	Activation of blood coagulation via clotting cascade →	-0.301	-1.046	.008	<.001	3	12
BONE	Integrin-mediated signaling pathway →	-0.295	-1.012	<.001	<.001	3	12
LIVER	Positive regulation of calcium ion transport into cytosol →	-0.296	-1.300	.001	.008	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,246 associations by consensus.

Tetrapyrrole biosynthetic process by COQ8A expression — PANCREAS

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