COQ8A

Across TCGA cell cohorts, COQ8A mutation is significantly associated with the RNA expression of many other genes, with 932 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COQ8A-associated genes across cancer lineages are GRK7, KYAT3, and STOX1. Each is linked with COQ8A in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ8A-to-partner and partner-to-COQ8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRK7 grouped by COQ8A-low versus COQ8A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ8A→partner) and Y-score (partner→COQ8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRK7 →	+0.075	+2.441	<.001	.001	3	2
LARGE_INTESTINE	KYAT3 →	+0.862	+2.628	<.001	.002	3	2
LARGE_INTESTINE	STOX1 →	+1.051	+3.082	<.001	.007	3	2
LARGE_INTESTINE	RIMKLA →	+0.618	+3.169	.001	.006	3	2
LARGE_INTESTINE	PAX9 →	+0.688	+2.628	.002	.002	3	2
URINARY_TRACT	RAMP3 →	+0.158	+4.217	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 932 associations by consensus.

GRK7 by COQ8A expression — LARGE_INTESTINE

Explore this box plot interactively →