COQ5

Across TCGA patient cohorts, COQ5 mutation is significantly associated with the RNA expression of many other genes, with 548 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ5-associated genes across cancer lineages are RN7SL223P, LYPLA1P2, and ABHD17AP8. Each is linked with COQ5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ5-to-partner and partner-to-COQ5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL223P grouped by COQ5-low versus COQ5-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ5→partner) and Y-score (partner→COQ5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL223P →	+0.078	+5.623	<.001	.001	3	2
HNSC	LYPLA1P2 →	+0.107	+3.364	<.001	.007	3	2
HNSC	ABHD17AP8 →	+0.074	+4.303	.002	.001	3	2
HNSC	ZNF833P →	+0.020	+3.517	.003	.008	3	2
UCEC	GSTA6P →	+0.066	+2.523	.002	.008	3	2
UCEC	DIP2A-IT1 →	+0.356	+2.529	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 548 associations by consensus.

RN7SL223P by COQ5 expression — HNSC

Explore this box plot interactively →