COQ5

Across TCGA patient cohorts, COQ5 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ5-associated genes across cancer lineages are GATA3, PCNA, and TIGAR. Each is linked with COQ5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ5-to-partner and partner-to-COQ5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA3 grouped by COQ5-low versus COQ5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ5→partner) and Y-score (partner→COQ5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA3 →	+0.195	+2.183	.049	.035	3	1
UCEC	PCNA →	+0.276	+3.321	.014	.010	3	1
UCEC	TIGAR →	+0.279	+2.196	<.001	.034	3	1
UCEC	ATM →	-0.680	-3.321	.004	.010	2	2
UCEC	GATA6 →	-0.191	-3.314	.018	.010	1	1
UCEC	MIG-6 →	+0.135	+3.335	.009	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GATA3 by COQ5 expression — UCEC

Explore this box plot interactively →