COQ3

Across TCGA pan-cancer cohorts, COQ3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COQ3 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher COQ3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COQ3 expression acts as an unfavorable survival marker, although some lineages such as OV and LSCC show a favorable association.

OV, HNSC, and LUAD are the cancer types where COQ3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.900	0.645	.011	16	view →
HNSC	DFS	Tertile	All	0.672	0.829	.017	15	view →
LUAD	OS	Tertile	II,III,IV	0.787	1.000	.013	15	view →
LSCC	DFS	Median	II,III,IV	0.824	0.546	.021	9	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
GBM	OS	Tertile	All	0.881	0.722	.007	4	view →
CCRCC	DFS	Median	All	0.704	1.000	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COQ3–OV (DFS)

Open the OV breakdown →