COQ10A

Across TCGA patient cohorts, COQ10A mutation is significantly associated with the RNA expression of many other genes, with 322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ10A-associated genes across cancer lineages are MED28P4, PRORY, and PGBD4P2. Each is linked with COQ10A in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ10A-to-partner and partner-to-COQ10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED28P4 grouped by COQ10A-low versus COQ10A-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ10A→partner) and Y-score (partner→COQ10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MED28P4 →	+0.394	+5.039	<.001	.008	3	2
UCEC	PRORY →	+0.026	+3.885	<.001	.008	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
UCEC	H2AC4 →	+0.649	+2.595	.001	.006	3	1
UCEC	MIR8070 →	+0.850	+2.302	<.001	.005	3	1
UCEC	H4C1 →	+0.652	+3.345	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 322 associations by consensus.

MED28P4 by COQ10A expression — READ

Explore this box plot interactively →