COPZ1

Across TCGA patient cohorts, COPZ1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPZ1-associated genes across cancer lineages are Ku80, STAT3_pY705, and STAT5a. Each is linked with COPZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPZ1-to-partner and partner-to-COPZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by COPZ1-low versus COPZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPZ1→partner) and Y-score (partner→COPZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.256	+2.183	.039	.035	3	1
UCEC	STAT3_pY705 →	-0.398	-2.999	.003	.035	3	1
UCEC	STAT5a →	+0.450	+3.321	.031	.010	3	1
UCEC	BRD4 →	+0.295	+2.177	.035	.035	3	1
UCEC	Caspase-8 →	-0.313	-3.169	.017	.019	3	1
UCEC	p27_pT198 →	+0.120	+3.321	.032	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by COPZ1 expression — UCEC

Explore this box plot interactively →