COPS9

Across TCGA pan-cancer cohorts, COPS9 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COPS9 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher COPS9 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COPS9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

LSCC, GBM, and HNSC are the cancer types where COPS9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.266	0.894	.031	11	view →
GBM	OS	Median	All	0.365	0.659	.015	9	view →
HNSC	OS	Tertile	III,IV	0.955	0.795	.029	7	view →
LUAD	OS	Median	II,III,IV	0.878	0.582	.047	4	view →
CCRCC	OS	Tertile	All	1.000	0.915	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COPS9–LSCC (DFS)

Open the LSCC breakdown →