COPS9

Across TCGA pan-cancer cohorts, COPS9 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of COPS9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where COPS9 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types COPS9 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC and CCRCC are the cancer types where COPS9 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COPS9 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.247	.001	6	view →
CCRCC	Female	All	+0.132	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

COPS9–HNSC

Open the HNSC breakdown →