COPS9

Across TCGA patient cohorts, COPS9 protein abundance is significantly associated with the RNA expression of many other genes, with 3,919 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible COPS9-associated genes across cancer lineages are DTD2, MIER3, and FRS2. Each is linked with COPS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS9-to-partner and partner-to-COPS9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COPS9 versus DTD2 in OV, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS9→partner) and Y-score (partner→COPS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DTD2 →	+0.600	+0.529	.001	.006	3	2
BRCA	MIER3 →	+0.750	+0.498	<.001	<.001	3	2
BRCA	FRS2 →	+1.161	+0.517	<.001	<.001	3	2
OV	FTCDNL1 →	+0.797	+0.666	.005	.002	3	2
OV	MTREX →	+0.708	+0.582	.005	.002	3	2
OV	DHX29 →	+0.834	+0.624	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,919 associations by consensus.

COPS9 vs DTD2 — OV

Explore this scatter interactively →