COPS9

Across TCGA patient cohorts, COPS9 mutation is significantly associated with the RNA expression of many other genes, with 422 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS9-associated genes across cancer lineages are MIR6893, MIR6077, and CATSPERE. Each is linked with COPS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS9-to-partner and partner-to-COPS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6893 grouped by COPS9-low versus COPS9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS9→partner) and Y-score (partner→COPS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6893 →	+0.801	+5.622	<.001	<.001	3	1
SKCM	MIR6077 →	+0.570	+4.695	<.001	.003	3	1
UCEC	CATSPERE →	-0.403	-3.448	.001	.005	3	1
UCEC	FCER1A →	-0.904	-3.459	.006	.005	3	1
UCEC	CCDC43 →	+0.591	+3.354	.005	.005	3	1
UCEC	HARBI1 →	+0.536	+3.502	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 422 associations by consensus.

MIR6893 by COPS9 expression — SKCM

Explore this box plot interactively →