COPS9

Across TCGA patient cohorts, COPS9 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS9-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and STAT3_pY705. Each is linked with COPS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS9-to-partner and partner-to-COPS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by COPS9-low versus COPS9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS9→partner) and Y-score (partner→COPS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.341	-3.000	.018	.037	3	1
UCEC	FoxM1 →	+0.334	+3.000	.025	.037	3	1
UCEC	STAT3_pY705 →	-0.576	-3.000	<.001	.037	3	1
UCEC	VHL →	-1.417	-3.000	<.001	.036	3	1
UCEC	Caspase-8 →	-0.400	-3.000	.005	.036	2	1
UCEC	4E-BP1 →	+0.497	+2.837	.001	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by COPS9 expression — UCEC

Explore this box plot interactively →