COPS9

Across TCGA cell cohorts, COPS9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,509 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible COPS9-associated GO terms across cancer lineages are Mitochondrial translational elongation, Positive regulation of ligase activity, and snoRNA guided rRNA pseudouridine synthesis. Each is linked with COPS9 in more than 12 cancer types. Because this analysis shows association rather than direction, both COPS9-to-partner and partner-to-COPS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial translational elongation grouped by COPS9-low versus COPS9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS9→partner) and Y-score (partner→COPS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitochondrial translational elongation →	+0.126	+0.896	<.001	.001	3	13
BONE	Positive regulation of ligase activity →	+0.133	+0.912	<.001	<.001	3	12
URINARY_TRACT	snoRNA guided rRNA pseudouridine synthesis →	+0.117	+0.987	<.001	.001	3	11
BLOOD_Leukemia	Positive regulation of endosome organization →	-0.103	-0.575	.004	<.001	3	11
LIVER	Positive regulation of plasma cell differentiation →	-0.141	-0.841	.006	.001	3	10
UPPER_AERODIGESTIVE_TRACT	tRNA threonylcarbamoyladenosine modification →	+0.094	+0.816	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,509 associations by consensus.

Mitochondrial translational elongation by COPS9 expression — BONE

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