Across TCGA pan-cancer cohorts, COPS8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated COPS8 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher COPS8 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated COPS8 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PRAD and UCEC are the cancer types where COPS8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	II,III,IV	1.000	0.445	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: COPS8 tumor-vs-normal RNA expression · all COPS8 data types