Across TCGA pan-cancer cohorts, COPS8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COPS8 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COPS8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COPS8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

LUAD, CCRCC, and UCEC are the cancer types where COPS8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.329	0.927	<.001	30	view →
CCRCC	DFS	Quartile	All	0.938	0.710	.014	10	view →
UCEC	DFS	Median	All	0.952	0.771	.006	8	view →
PDAC	OS	Quartile	All	0.563	0.298	.027	2	view →
HNSC	OS	Quartile	IV	1.000	0.923	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: COPS8 tumor-vs-normal RNA expression · all COPS8 data types