Across TCGA patient cohorts, COPS8 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,389 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible COPS8-associated proteins across cancer lineages are CUL3, SEC11C, and LOXL2. Each is linked with COPS8 in more than 6 cancer types. Because this analysis shows association rather than direction, both COPS8-to-partner and partner-to-COPS8 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS8→partner) and Y-score (partner→COPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CUL3 →	+0.220	+0.392	<.001	<.001	3	7
HNSC	SEC11C →	-1.301	-0.569	<.001	<.001	3	5
PDAC	LOXL2 →	+0.713	+0.333	.001	<.001	3	5
BRCA	CD38 →	-0.767	-0.326	<.001	.004	3	5
HNSC	MZB1 →	-1.090	-0.619	<.001	<.001	3	5
PDAC	DBN1 →	+0.452	+0.363	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,389 associations by consensus.

Exploration

COPS8 survival (RNA) · tumor vs normal (RNA) · all COPS8 data types