Across TCGA patient cohorts, COPS8 protein abundance is significantly associated with the RNA expression of many other genes, with 6,395 significant associations in total. COAD shows the largest number of these associations.

The most reproducible COPS8-associated genes across cancer lineages are DTWD1, BBS4, and STX8. Each is linked with COPS8 in more than 2 cancer types. Because this analysis shows association rather than direction, both COPS8-to-partner and partner-to-COPS8 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS8→partner) and Y-score (partner→COPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DTWD1 →	+0.429	+0.136	<.001	.004	3	3
BRCA	BBS4 →	+0.689	+0.187	<.001	.001	3	3
COAD	STX8 →	+0.549	+0.154	<.001	<.001	3	3
COAD	RPS27L →	+0.634	+0.122	<.001	<.001	3	3
UCEC	TXNDC15 →	+0.592	+0.131	.001	.001	3	3
BRCA	KIF14 →	-0.887	-0.246	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,395 associations by consensus.

Exploration

COPS8 survival (RNA) · tumor vs normal (RNA) · all COPS8 data types