Across TCGA patient cohorts, COPS8 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS8-associated genes across cancer lineages are eIF4E, ERK2, and FOXO3a_pS318_S321. Each is linked with COPS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS8-to-partner and partner-to-COPS8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS8→partner) and Y-score (partner→COPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.209	+2.115	.023	.019	3	1
UCEC	ERK2 →	+0.192	+2.115	.022	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-2.115	.033	.019	3	1
UCEC	ACC1 →	+0.386	+2.820	.015	.035	3	1
UCEC	p62 Lck ligand →	+0.492	+3.459	<.001	.005	3	1
UCEC	Rab25 →	-0.402	-2.115	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

COPS8 survival (RNA) · tumor vs normal (RNA) · all COPS8 data types