Across TCGA cell cohorts, COPS8 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COPS8-associated genes across cancer lineages are RASGEF1C, IFNA5, and SLC38A8. Each is linked with COPS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS8-to-partner and partner-to-COPS8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS8→partner) and Y-score (partner→COPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RASGEF1C →	+0.197	+3.555	.008	.003	3	1
LARGE_INTESTINE	IFNA5 →	+0.037	+2.657	<.001	.007	3	1
LARGE_INTESTINE	SLC38A8 →	+0.693	+3.404	<.001	.006	3	1
LARGE_INTESTINE	SLN →	+0.130	+3.706	.006	.002	3	1
LARGE_INTESTINE	FBXW10 →	+0.223	+3.491	.001	.004	3	1
LARGE_INTESTINE	NUTM1 →	+0.069	+3.672	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

COPS8 survival (RNA) · tumor vs normal (RNA) · all COPS8 data types