COPS7A

Across TCGA pan-cancer cohorts, COPS7A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COPS7A data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COPS7A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COPS7A expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where COPS7A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.908	0.621	.014	19	view →
CCRCC	OS	Quartile	All	1.000	0.437	.011	13	view →
LUAD	DFS	Quartile	III,IV	0.372	0.996	.006	8	view →
UCEC	DFS	Quartile	III,IV	0.417	1.000	.040	4	view →
LSCC	DFS	Median	III,IV	0.932	0.655	.030	3	view →
HNSC	DFS	Median	II,III,IV	0.911	0.981	.009	3	view →
GBM	DFS	Median	All	0.827	0.674	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COPS7A–PDAC (DFS)

Open the PDAC breakdown →