COPS6

Across TCGA pan-cancer cohorts, COPS6 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated COPS6 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher COPS6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated COPS6 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA and UCEC are the cancer types where COPS6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.152	0.625	.012	18	view →
UCEC	DFS	Median	All	1.000	0.623	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

COPS6–BLCA (DFS)

Open the BLCA breakdown →