COPS6

Across TCGA pan-cancer cohorts, COPS6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COPS6 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COPS6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COPS6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

LUAD, CCRCC, and COAD are the cancer types where COPS6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.247	0.805	.001	42	view →
CCRCC	DFS	Median	III,IV	0.985	0.144	.008	39	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	12	view →
LSCC	OS	Quartile	III,IV	0.448	0.868	.032	2	view →
HNSC	DFS	Tertile	II,III,IV	0.914	0.966	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COPS6–LUAD (DFS)

Open the LUAD breakdown →