COPS6

Across TCGA patient cohorts, COPS6 protein abundance is significantly associated with the RNA expression of many other genes, with 5,671 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible COPS6-associated genes across cancer lineages are E2F8, TTK, and GGH. Each is linked with COPS6 in more than 3 cancer types. Because this analysis shows association rather than direction, both COPS6-to-partner and partner-to-COPS6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COPS6 versus E2F8 in UCEC, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS6→partner) and Y-score (partner→COPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	E2F8 →	-0.891	-0.152	<.001	.004	3	4
BRCA	TTK →	-0.992	-0.172	<.001	<.001	3	4
OV	GGH →	-1.065	-0.190	.004	.006	3	3
HNSC	BCL2A1 →	-1.154	-0.268	.007	<.001	2	4
BRCA	FAM83D →	-0.968	-0.187	<.001	<.001	3	3
BRCA	CENPO →	-0.489	-0.278	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,671 associations by consensus.

COPS6 vs E2F8 — UCEC

Explore this scatter interactively →