COPS6

Across TCGA cell cohorts, COPS6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,451 significant associations in total. CNS shows the largest number of these associations.

The most reproducible COPS6-associated GO terms across cancer lineages are Positive regulation of mitotic cell cycle phase transition, Positive regulation of DNA-templated DNA replication, and Protein depolymerization. Each is linked with COPS6 in more than 11 cancer types. Because this analysis shows association rather than direction, both COPS6-to-partner and partner-to-COPS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cell cycle phase transition grouped by COPS6-low versus COPS6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS6→partner) and Y-score (partner→COPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cell cycle phase transition →	+0.108	+0.914	.001	.002	2	12
BONE	Positive regulation of DNA-templated DNA replication →	+0.124	+0.498	.004	.002	3	10
LUNG_NSCLC_LUSC	Protein depolymerization →	+0.101	+0.815	.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Meiotic cell cycle →	+0.088	+0.886	.001	.008	2	11
UPPER_AERODIGESTIVE_TRACT	Nucleosome disassembly →	+0.102	+0.800	.001	.002	3	10
SOFT_TISSUE	Pre-mRNA catabolic process →	+0.169	+0.791	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,451 associations by consensus.

Positive regulation of mitotic cell cycle phase transition by COPS6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →