Q-omics provides the consensus-scored COPS5P2 profile across patient tissues and cancer cell-line models. COPS5P2 expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, COPS5P2 is differentially expressed in 6, with the highest sampling consensus in UCEC. Additionally, COPS5P2 RNA expression shows 12,629 significant gene co-expression associations, with the highest sampling consensus in DLBC. Together, these results highlight LUSC, UCEC, and DLBC as cancer lineages where COPS5P2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for COPS5P2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes COPS5P2 survival associations across molecular data types. COPS5P2 RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible COPS5P2 RNA expression–survival associations across cancer types. High COPS5P2 expression shows unfavorable associations in LUSC, HNSC and THCA, but favorable associations in LUAD, KICH and SARC. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify LUSC as the clearest survival context for COPS5P2 RNA expression.
This table summarizes COPS5P2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for COPS5P2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. COPS5P2 shows lower tumor expression in UCEC, BRCA, LUSC, HNSC and THCA and higher tumor expression in COAD. The UCEC box plot shows higher COPS5P2 RNA expression in normal versus tumor tissue (log2 FC = −0.383, t-test p = .002).
This table shows molecular features associated with COPS5P2 in patient tissues and cancer cell lines. In patient samples, COPS5P2 shows the broadest associations at the RNA and protein expression levels, with DLBC recurring as the lineage with the largest associated feature set.
