COPS4

Across TCGA pan-cancer cohorts, COPS4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COPS4 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher COPS4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COPS4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where COPS4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.955	0.305	.005	44	view →
PDAC	DFS	Quartile	II,III,IV	0.480	0.279	.010	11	view →
LUAD	DFS	Median	III,IV	0.305	0.673	.034	4	view →
LSCC	OS	Quartile	III,IV	0.448	0.868	.032	4	view →
HNSC	OS	Median	II,III,IV	0.912	0.817	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COPS4–CCRCC (DFS)

Open the CCRCC breakdown →