COPS4

Across TCGA patient cohorts, COPS4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,065 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COPS4-associated proteins across cancer lineages are RAC2, ANKRD17, and ENOPH1. Each is linked with COPS4 in more than 4 cancer types. Because this analysis shows association rather than direction, both COPS4-to-partner and partner-to-COPS4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COPS4 versus RAC2 in GBM, with a Pearson correlation of -0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS4→partner) and Y-score (partner→COPS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAC2 →	-0.708	-0.281	<.001	<.001	3	5
OV	ANKRD17 →	+0.365	+0.347	<.001	.008	3	5
BRCA	ENOPH1 →	+0.318	+0.543	<.001	<.001	3	5
HNSC	TMF1_S344 →	-0.431	-0.790	<.001	.001	3	4
GBM	THEMIS2 →	-0.460	-0.253	.001	.001	3	4
GBM	TNFAIP8 →	-0.668	-0.270	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,065 associations by consensus.

COPS4 vs RAC2 — GBM

Explore this scatter interactively →